Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Clptm1ltm1d(EUCOMM)Wtsi mutation
(0 available);
any
Clptm1l mutation
(34 available)
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mortality/aging
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• only 5 of 37 pups born survive past postnatal day 2
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• fewer than 15% of the born pups survive past postnatal day 2
• however, pups that survive the neonatal period are healthy, fertile and indistinguishable from wild-type controls
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• mice are born at a significantly lower than expected frequency from heterozygous mating pairs
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immune system
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N |
• surviving mice show no differences in the development, maturation and differentiation of B-lymphocytes into antibody secreting cells or in immunoglobulin class-switch recombination relative to wild-type controls
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Allelic
Composition |
Clptm1ltm1d(EUCOMM)Wtsi/Clptm1l+
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Genetic
Background |
involves: 129S4/SvJaeSor * BALB/cJ * C57BL/6N |
| Cell Lines |
EPD0460_2_E07 |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Clptm1ltm1d(EUCOMM)Wtsi mutation
(0 available);
any
Clptm1l mutation
(34 available)
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immune system
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• in vitro, the proportion of B cells that have undergone class-switch recombination following T cell-dependent stimulation is significantly higher than that in wild-type cells
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hematopoietic system
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• in vitro, the proportion of B cells that have undergone class-switch recombination following T cell-dependent stimulation is significantly higher than that in wild-type cells
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|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Clptm1ltm1d(EUCOMM)Wtsi mutation
(0 available);
any
Clptm1l mutation
(34 available)
Prdm1tm1Nutt mutation
(1 available);
any
Prdm1 mutation
(64 available)
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immune system
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N |
• mice show no significant differences in the frequency of bone marrow plasma cells, splenic plasma cells and splenic plasmablasts, or in the serum concentrations of IgM, IgG1, IgG2b, IgG2c, IgG3 or IgA relative to wild-type controls
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Analysis Tools