Phenotypes associated with this allele

• Allele Symbol: Gimap5^tm1Yout
• Allele Name: targeted mutation 1, Yousuke Takahama
• Allele ID: MGI:6280692
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gimap5^tm1Yout/Gimap5^tm1Yout	involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj	MGI:6286504

Genotype
MGI:6286504

hm1

• Allelic Composition: Gimap5^tm1Yout/Gimap5^tm1Yout
• Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:209926 )

N • normal thymocyte cellularity

hematopoietic system

hematopoietic system phenotype ( J:209926 )

N • normal cellularity of B cells

N • normal expression of CD44 and CD62L in CD4+ T cells and CD8+ T cells in spleen

decreased T cell number ( J:209926 )

• significant decrease in CD8+ T cell numbers in spleen and lymph nodes

• reduced anti-CD3 and anti-CD28 stimulated survival of CD8+ T cells in vitro

• normal Il7-stimulated survival of T cells in vitro

• normal cellularity of NK1.1+ CD3-, NK1.1+ CD3+, CD4+ T cells in spleen and lymph nodes

immune system

decreased T cell number ( J:209926 )

• significant decrease in CD8+ T cell numbers in spleen and lymph nodes

• reduced anti-CD3 and anti-CD28 stimulated survival of CD8+ T cells in vitro

• normal Il7-stimulated survival of T cells in vitro

• normal cellularity of NK1.1+ CD3-, NK1.1+ CD3+, CD4+ T cells in spleen and lymph nodes