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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Map3k3tm1.2Mlkn
targeted mutation 1.2, Mark Kahn
MGI:6279294
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Map3k3tm1.1Mlkn/Map3k3tm1.2Mlkn
Nfatc1tm1.1(cre)Bz/Nfatc1+ 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac MGI:6279295


Genotype
MGI:6279295
cn1
Allelic
Composition		 Map3k3tm1.1Mlkn/Map3k3tm1.2Mlkn
Nfatc1tm1.1(cre)Bz/Nfatc1+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map3k3tm1.1Mlkn mutation (0 available); any Map3k3 mutation (25 available)
Map3k3tm1.2Mlkn mutation (0 available); any Map3k3 mutation (25 available)
Nfatc1tm1.1(cre)Bz mutation (0 available); any Nfatc1 mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis ( J:238897 )
• embryonic lethality prior to E12.5

cardiovascular system
thin myocardium ( J:238897 )
• thin myocardial cell layer
• however, cardiac jelly is preserved and endocardial-myocardial separation at E10.5 is normal

muscle
thin myocardium ( J:238897 )
• thin myocardial cell layer
• however, cardiac jelly is preserved and endocardial-myocardial separation at E10.5 is normal




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory