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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mab21l2em1(IMPC)Mbp
endonuclease-mediated mutation 1, Mouse Biology Program, UC Davis
MGI:6276927
Summary 2 genotypes


Genotype
MGI:6288558
hm1
Allelic
Composition		 Mab21l2em1(IMPC)Mbp/Mab21l2em1(IMPC)Mbp
Genetic
Background		 C57BL/6NCrl-Mab21l2em1(IMPC)Mbp/Mmucd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mab21l2em1(IMPC)Mbp mutation (1 available); any Mab21l2 mutation (21 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system

mortality/aging
embryonic lethality prior to organogenesis, complete penetrance ( J:374598 )
• contrary to expectations, only a single resorbing homozygous embryo was recovered from heterozygous intercrosses at E8.5-E9.5; no further phenotype characterization was undertaken




Genotype
MGI:6461416
ht2
Allelic
Composition		 Mab21l2em1(IMPC)Mbp/Mab21l2+
Genetic
Background		 C57BL/6NCrl-Mab21l2em1(IMPC)Mbp/Mmucd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mab21l2em1(IMPC)Mbp mutation (1 available); any Mab21l2 mutation (21 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological

cardiovascular system

embryo

growth/size/body
embryonic growth retardation ( J:211773 )
IMPC - UCD

homeostasis/metabolism

nervous system

vision/eye
microphthalmia ( J:211773 )
IMPC - UCD
anophthalmia ( J:211773 )
IMPC - UCD




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory