About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Iglon5em1(IMPC)Mbp
endonuclease-mediated mutation 1, Mouse Biology Program, UC Davis
MGI:6276893
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Iglon5em1(IMPC)Mbp/Iglon5em1(IMPC)Mbp C57BL/6NCrl-Iglon5em1(IMPC)Mbp/Mmucd MGI:6492893


Genotype
MGI:6492893
hm1
Allelic
Composition		 Iglon5em1(IMPC)Mbp/Iglon5em1(IMPC)Mbp
Genetic
Background		 C57BL/6NCrl-Iglon5em1(IMPC)Mbp/Mmucd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Iglon5em1(IMPC)Mbp mutation (1 available); any Iglon5 mutation (19 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal sucrose solution preference ( J:345884 )
• males exhibit lower sucrose preference, indicating depressive-like behavior
anhedonia ( J:345884 )
• males exhibit lower sucrose preference, indicating depressive-like behavior
impaired balance ( J:345884 )
• 2-month-old mice show a greater number of slips in the beam balance test; males lose their balance more times than wild-type mice and while females show more slips, significance is not reached
• however, time spent to cross the beam is not different, indicating that loss of balance is not attributed to deficits in muscle strength
• however, both male and female mice exhibit normal gait, hippocampal-dependent spatial memory, and normal behavior in the black and white test box, social interaction test, tail suspension test, and the open field
hyperactivity ( J:345884 )
• females, but not males, exhibit hyperactive behavior during the daytime, showing a consistent increase of back-and-forth movements across the box compared to wild-type females
• females maintain the hyperactivity during the nighttime
increased vertical activity ( J:345884 )
• females show a higher number of daytime rearing
abnormal nest building behavior ( J:345884 )
• males, but not females, exhibit excessive nest-building activity, building better and larger nests and using more material compared to wild-type males

endocrine/exocrine glands

growth/size/body
enlarged kidney ( J:211773 )
IMPC - UCD
enlarged spleen ( J:211773 )
IMPC - UCD

hematopoietic system
enlarged spleen ( J:211773 )
IMPC - UCD

immune system
enlarged spleen ( J:211773 )
IMPC - UCD

integument

liver/biliary system

nervous system
nervous system phenotype ( J:345884 )
N
• mice show normal brain weight and no brain abnormalities, including no phospho-tau deposits at 22 months of age

renal/urinary system
enlarged kidney ( J:211773 )
IMPC - UCD
small kidney ( J:211773 )
IMPC - UCD

reproductive system

vision/eye




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory