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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Cox7a2ls
short
MGI:6276120
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Cox7a2ls/Cox7a2ls C57BL/6JCrl MGI:6276127


Genotype
MGI:6276127
hm1
Allelic
Composition
Cox7a2ls/Cox7a2ls
Genetic
Background
C57BL/6JCrl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cox7a2ls mutation (8 available); any Cox7a2l mutation (60 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• mitochondria exhibit increased oxygen succinate or pyruvate and malate-driven rates of oxygen-consumption and ATP synthesis producing higher respiration rates compared with mitochondria expressing the long isoform of Cox7a2ll
• mitochondria from mice fed ad libitum fail to exhibit an additive effect on maximum respiration stimulated by a combination of pyruvate and malate unlike in mitochondria from Hsd:ICR mice
• mitochondria from fasted mice fail to exhibit an increase in succinate respiration unlike in mitochondria from Hsd:ICR mice
• however, respiration rates driven by response to pyruvate, malate and succinate are normal





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
07/02/2024
MGI 6.13
The Jackson Laboratory