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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
transgene insertion, Joan Heller Brown
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
Tg(Myh6-Camk2d_ic)#Jhb/0 Not Specified MGI:6276135

Not Specified
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phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• after AV node ablation, hearts show higher intrinsic ventricular heart rates
• application of 2 consecutive premature beats via programmed electrical stimulation induces monomorphic and polymorphic ventricular tachyarrhythmias
• isoproterenol infusion induces monomorphic ventricular tachyarrhythmias in mutants while it only increases the heart rate with no arrhythmias in wild-type mice
• the effective refractory period is decreased in hearts
• corrected QT interval is prolonged indicating prolonged repolarization
• monocytes show slower fast sodium current inactivation, enhanced late sodium current, increased intracellular sodium concentration, enhanced accumulation of intermediate sodium current inactivation, slower recovery from inactivation and a shift of steady-state inactivation of sodium channels to more negative membrane potential

nervous system
• at lower pacing frequencies, monophasic action potential duration is prolonged in hearts
• however, at high pacing frequencies, monophasic action potential duration is normal

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
congestive heart failure DOID:6000 J:117345

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory