Phenotypes associated with this allele

• Allele Symbol: Nf1^{tm1d(KOMP)Wtsi}
• Allele Name: targeted mutation 1d, Wellcome Trust Sanger Institute
• Allele ID: MGI:6275187
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nf1^tm1d(KOMP)Wtsi/Nf1^tm1d(KOMP)Wtsi	involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6N * FVB/N	MGI:6275190
ht2	Nf1^tm1d(KOMP)Wtsi/Nf1^tm2.1Kest	involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6N * FVB/N	MGI:6275188

Genotype
MGI:6275190

hm1

• Allelic Composition: Nf1^{tm1d(KOMP)Wtsi}/Nf1^{tm1d(KOMP)Wtsi}
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6N * FVB/N
• Cell Lines: EPD0033_1_F12

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:234172 )

• embryos fail to develop past E9.5 and all die by E10

Genotype
MGI:6275188

ht2

• Allelic Composition: Nf1^{tm1d(KOMP)Wtsi}/Nf1^tm2.1Kest
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6N * FVB/N
• Cell Lines: EPD0033_1_F12

normal phenotype

no abnormal phenotype detected ( J:234172 )

• mice are viable and display no overt phenotype, with no tumor development up to 24 months of age