Phenotypes associated with this allele

• Allele Symbol: Mir214^tm1.1Eno
• Allele Name: targeted mutation 1.1, Eric N Olson
• Allele ID: MGI:6275029
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mir214^tm1.1Eno/Mir214^tm1.1Eno	involves: C57BL/6	MGI:6275034

Genotype
MGI:6275034

hm1

• Allelic Composition: Mir214^tm1.1Eno/Mir214^tm1.1Eno
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:184550 )

N • mice exhibit normal baseline cardiac structure and function

increased myocardial fiber size ( J:184550 )

• slight increase in cardiomyocyte size following cardiac ischemia and reperfusion

cardiac fibrosis ( J:184550 )

• following cardiac ischemia and reperfusion

abnormal myocardial fiber physiology ( J:184550 )

• at physiological extracellular calcium concentrations, cardiomyocytes exhibit lower levels of intracellular calcium transients compared with wild-type cells

• in the presence of high extracellular calcium, cardiomyocytes exhibit increased intrace4llular calcium transients compared with wild-type cells

• however, decay rates under either condition are normal

increased cardiomyocyte apoptosis ( J:184550 )

• following cardiac ischemia and reperfusion

abnormal response to cardiac infarction ( J:184550 )

• following cardiac ischemia and reperfusion, mice exhibit increased myocyte apoptosis, fibrosis and myocyte size compared with wild-type mice

• however, infiltrating leukocyte numbers and mitochondrial function are normal

increased myocardial infarct size ( J:184550 )

• following cardiac ischemia and reperfusion

cellular

increased cardiomyocyte apoptosis ( J:184550 )

• following cardiac ischemia and reperfusion

homeostasis/metabolism

abnormal response to cardiac infarction ( J:184550 )

• following cardiac ischemia and reperfusion, mice exhibit increased myocyte apoptosis, fibrosis and myocyte size compared with wild-type mice

• however, infiltrating leukocyte numbers and mitochondrial function are normal

increased myocardial infarct size ( J:184550 )

• following cardiac ischemia and reperfusion

muscle

increased myocardial fiber size ( J:184550 )

• slight increase in cardiomyocyte size following cardiac ischemia and reperfusion

increased cardiomyocyte apoptosis ( J:184550 )

• following cardiac ischemia and reperfusion