Phenotypes associated with this allele

• Allele Symbol: Lctl^tm1.1Gwis
• Allele Name: targeted mutation 1.1 Graeme Wistow
• Allele ID: MGI:6274975
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lctl^tm1.1Gwis/Lctl^tm1.1Gwis	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:6274994

Genotype
MGI:6274994

hm1

• Allelic Composition: Lctl^tm1.1Gwis/Lctl^tm1.1Gwis
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal lens morphology ( J:269554 )

• defects in lens optics by 9 months of age, progressive and leading to distorted image formation

abnormal lens development ( J:269554 )

• lens suture defects are noted at 6 weeks of age; sutures appear 'X' or double 'Y' shaped in contrast to the 'Y' shaped posterior sutures in control mice

cortical cataract ( J:269554 )

• age related cortical cataracts develop by 9 months of age