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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Spring1em1Nki
endonuclease-mediated mutation 1, The Netherlands Cancer Institute
MGI:6274678
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Spring1em1Nki/Spring1em1Nki involves: C57BL/6J MGI:6437880


Genotype
MGI:6437880
hm1
Allelic
Composition		 Spring1em1Nki/Spring1em1Nki
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spring1em1Nki mutation (0 available); any Spring1 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

embryo
abnormal embryo development ( J:287088 )
• abnormally developed embryos at E7.5
decreased embryo size ( J:287088 )
• embryos are smaller at E7.5
abnormal allantois morphology ( J:287088 )
• E7.5 embryos show a poorly developed allantois
abnormal amniotic cavity morphology ( J:287088 )
• E7.5 embryos show a poorly developed amniotic cavity

growth/size/body
decreased embryo size ( J:287088 )
• embryos are smaller at E7.5




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory