Phenotypes associated with this allele

• Allele Symbol: Tlk2^tm1Strc
• Allele Name: targeted mutation 1, Travis H Stracker
• Allele ID: MGI:6274360
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tlk2^tm1Strc/Tlk2^tm1Strc	Not Specified	MGI:6274366
cx2	Tlk1^Gt(E067A02)Wrst/Tlk1^Gt(E067A02)Wrst Tlk2^tm1Strc/Tlk2^+	involves: 129P2/OlaHsd * C57BL/6J	MGI:6274370

Genotype
MGI:6274366

hm1

• Allelic Composition: Tlk2^tm1Strc/Tlk2^tm1Strc
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:268910 )

• die between E13.5 and E15.5

embryo

decreased embryo size ( J:268910 )

• smaller at E10.5 - E13.5

small placenta ( J:268910 )

• smaller at E14.5

pale placenta ( J:268910 )

• lack of blood circulation at E14.5

hematopoietic system

anemia ( J:268910 )

• appear anemic at E10.5 - E13.5

growth/size/body

decreased embryo size ( J:268910 )

• smaller at E10.5 - E13.5

Genotype
MGI:6274370

cx2

• Allelic Composition: Tlk1^{Gt(E067A02)Wrst}/Tlk1^{Gt(E067A02)Wrst}; Tlk2^tm1Strc/Tlk2⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

mortality/aging

premature death ( J:268910 )

• all moribund by 1 month of age due to lack of mobility and tremors

growth/size/body

decreased body size ( J:268910 )

• severely runted at p2 - p25

behavior/neurological

tremors ( J:268910 )

decreased locomotor activity ( J:268910 )

• lack of mobility