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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Trim13tm1.1Jskg
targeted mutation 1.1, Joonsoo Kang
MGI:6270360
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Trim13tm1.1Jskg/Trim13tm1.1Jskg B6.129S7(Cg)-Trim13tm1.1Jskg MGI:6270368


Genotype
MGI:6270368
hm1
Allelic
Composition		 Trim13tm1.1Jskg/Trim13tm1.1Jskg
Genetic
Background		 B6.129S7(Cg)-Trim13tm1.1Jskg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trim13tm1.1Jskg mutation (0 available); any Trim13 mutation (54 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased susceptibility to Picornaviridae infection induced morbidity/mortality ( J:243916 )
• female mice infected with a lethal dose of encephalomyocarditis virus (EMCV) have a mean survival time of 143.3 h after infection compared with wild-type mice that survive 101.4 h
• however, male mice exhibit normal survival and mice infected with vesicular stomatitis virus (VSV) exhibit normal survival

immune system
abnormal circulating interferon level ( J:243916 )
• increased type I IFN serum levels 5 h after infection with a high dose of EMCV in female mice
• however, response to influenza A virus infection is normal
decreased circulating interferon-beta level ( J:243916 )
• 20 h after intranasal VSV infection in female mice
increased interferon-beta secretion ( J:243916 )
• from mouse embryonic fibroblasts exposed to poly(I.C) or EMCV
• however, response to Sendai virus is normal
decreased susceptibility to Picornaviridae infection induced morbidity/mortality ( J:243916 )
• female mice infected with a lethal dose of encephalomyocarditis virus (EMCV) have a mean survival time of 143.3 h after infection compared with wild-type mice that survive 101.4 h
• however, male mice exhibit normal survival and mice infected with vesicular stomatitis virus (VSV) exhibit normal survival

homeostasis/metabolism
abnormal circulating interferon level ( J:243916 )
• increased type I IFN serum levels 5 h after infection with a high dose of EMCV in female mice
• however, response to influenza A virus infection is normal
decreased circulating interferon-beta level ( J:243916 )
• 20 h after intranasal VSV infection in female mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/30/2024
MGI 6.23 		The Jackson Laboratory