Phenotypes associated with this allele

• Allele Symbol: Nek8^m1Btlr
• Allele Name: mutation 1, Bruce Beutler
• Allele ID: MGI:6268750
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nek8^m1Btlr/Nek8^m1Btlr	C57BL/6J-Nek8^m1Btlr	MGI:6268752

Genotype
MGI:6268752

hm1

• Allelic Composition: Nek8^m1Btlr/Nek8^m1Btlr
• Genetic Background: C57BL/6J-Nek8^m1Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased susceptibility to induced colitis ( J:267544 )

• at day 7 and 10 after DSS treatment

decreased effector memory CD4-positive, alpha-beta T cell number ( J:267544 )

• in the peripheral blood

increased CD4-positive, alpha-beta T cell number ( J:267544 )

• in the peripheral blood

decreased CD8-positive, alpha-beta T cell number ( J:267544 )

• in the peripheral blood

decreased effector memory CD8-positive, alpha-beta T cell number ( J:267544 )

• in the peripheral blood

cardiovascular system

increased mean systemic arterial blood pressure ( J:267544 )

increased systemic arterial diastolic blood pressure ( J:267544 )

increased systemic arterial systolic blood pressure ( J:267544 )

digestive/alimentary system

increased susceptibility to induced colitis ( J:267544 )

• at day 7 and 10 after DSS treatment

hematopoietic system

decreased effector memory CD4-positive, alpha-beta T cell number ( J:267544 )

• in the peripheral blood

increased CD4-positive, alpha-beta T cell number ( J:267544 )

• in the peripheral blood

decreased CD8-positive, alpha-beta T cell number ( J:267544 )

• in the peripheral blood

decreased effector memory CD8-positive, alpha-beta T cell number ( J:267544 )

• in the peripheral blood