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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nup210enuI476T
enuI476T
MGI:6268316
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Nup210enuI476T/Nup210enuI476T involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:6268327
ht2
 		Nup210enuI476T/Nup210tm1a(EUCOMM)Hmgu involves: 129S1/Sv * 129X1/SvJ * C57BL/6N MGI:6268328


Genotype
MGI:6268327
hm1
Allelic
Composition		 Nup210enuI476T/Nup210enuI476T
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nup210enuI476T mutation (0 available); any Nup210 mutation (85 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal alpha-beta T cell morphology ( J:266693 )
• decreased CD4:CD8 ratio in the peripheral blood
decreased CD4-positive, alpha-beta T cell number ( J:266693 )
• in the spleen at 5 to 6 weeks of age

hematopoietic system
abnormal alpha-beta T cell morphology ( J:266693 )
• decreased CD4:CD8 ratio in the peripheral blood
decreased CD4-positive, alpha-beta T cell number ( J:266693 )
• in the spleen at 5 to 6 weeks of age




Genotype
MGI:6268328
ht2
Allelic
Composition		 Nup210enuI476T/Nup210tm1a(EUCOMM)Hmgu
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nup210enuI476T mutation (0 available); any Nup210 mutation (85 available)
Nup210tm1a(EUCOMM)Hmgu mutation (0 available); any Nup210 mutation (85 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased CD4-positive, alpha-beta T cell number ( J:266693 )
• mice exhibit the same phenotype as in Nup210ENUI476T homozygotes

hematopoietic system
decreased CD4-positive, alpha-beta T cell number ( J:266693 )
• mice exhibit the same phenotype as in Nup210ENUI476T homozygotes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory