Phenotypes associated with this allele

• Allele Symbol: Tg(Dct-Hes1)#Nshk
• Allele Name: transgene insertion, Shin-Ichi Nishikawa
• Allele ID: MGI:6267303
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Dct-Hes1)#Nshk/0	Not Specified	MGI:6267319

Genotype
MGI:6267319

tg1

• Allelic Composition: Tg(Dct-Hes1)#Nshk/0
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Attenuation of DAPT-induced apoptosis in Tg(Dct-Hes1)#Nshk/0 skin

pigmentation

pigmentation phenotype ( J:111228 )

N • when E13.5 dorsal skin is cultured in the presence of DAPT (a gamma-secretase inhibitor that blocks Notch signaling) and grafted onto a nude mouse, hairs grown from DAPT-treated wild-type skin are unpigmented both at 1 week and at 3 months of age (due to elimination of melanoblasts by apoptosis), whereas hairs grown from DAPT-treated transgenic skin show normal pigmentation indicating rescue of DAPT-induced hair graying

embryo

decreased melanoblast apoptosis ( J:111228 )

• when E13.5 dorsal skin is organ cultured in the presence of DAPT, most Dct+ and Pax3+ melanoblasts remain in the epidermis indicating attenuation of DAPT-induced apoptosis in transgenic skin

cellular

decreased melanoblast apoptosis ( J:111228 )

• when E13.5 dorsal skin is organ cultured in the presence of DAPT, most Dct+ and Pax3+ melanoblasts remain in the epidermis indicating attenuation of DAPT-induced apoptosis in transgenic skin