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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gt(ROSA)26Sortm1.2(CAG-PLS3,-GFP)Bwir
targeted mutation 1.2, Brunhilde Wirth
MGI:6267028
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Gt(ROSA)26Sortm1.2(CAG-PLS3,-GFP)Bwir/Gt(ROSA)26Sor+ B6N.Cg-Gt(ROSA)26Sortm1.1(CAG-PLS3,-GFP)Bwir MGI:6267046


Genotype
MGI:6267046
ht1
Allelic
Composition		 Gt(ROSA)26Sortm1.2(CAG-PLS3,-GFP)Bwir/Gt(ROSA)26Sor+
Genetic
Background		 B6N.Cg-Gt(ROSA)26Sortm1.1(CAG-PLS3,-GFP)Bwir
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1.2(CAG-PLS3,-GFP)Bwir mutation (0 available); any Gt(ROSA)26Sor mutation (1046 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
decreased osteoclast cell number ( J:267292 )
• at P5, but no at 3M
increased compact bone thickness ( J:267292 )
• in female, but not male, mice
decreased bone trabecula number ( J:267292 )
• however, trabecular bone thickness is normal
increased bone stiffness ( J:267292 )
• in female, but not male, mice
increased bone strength ( J:267292 )
• in female, but not male, mice

immune system
decreased osteoclast cell number ( J:267292 )
• at P5, but no at 3M

hematopoietic system
decreased osteoclast cell number ( J:267292 )
• at P5, but no at 3M




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory