All Phenotypes Tg(Tyr-HRAS*G12V)#Acc MGI Mouse

diluted coat color ( J:90877 )

• soon after birth, mice exhibit a light grayish brown (muted agouti) coat color

pigment incontinence ( J:90877 )

• mice show extensive deposition of melanin within the reticular dermis and upper dermal region

abnormal extracutaneous pigmentation ( J:90877 )

abnormal choroid pigmentation ( J:90877 )

• at 10-16 weeks of age, uveal tissue is thickened and heavily pigmented

abnormal choroid melanocyte morphology ( J:90877 )

• heavily pigmented benign melanocytic lesions of the choroid are observed

abnormal otic pigmentation ( J:90877 )

• at 10-16 weeks of age, pigmentation is observed in the inner ear

increased melanocyte number ( J:90877 )

• mice show increased numbers of melanocytes both in hair bulbs and in the dermal layer of the skin

hyperpigmentation ( J:90877 )

• the skin of the snout, ears, neck region, feet, and tail is darkly pigmented by 1-2 weeks of age, unlike in control littermates

• at 10-16 weeks of age, pigmentation is noted in the choroid plexus of the fourth ventricle, dura mater (meninges), choroid of the eye, periocular fascia, and inner ear

• the cervical lymph nodes and Kupffer cells of the liver also contain melanin, which appears to be contained in phagocytic cells

increased ear pigmentation ( J:90877 )

• the ears are darkly pigmented, unlike in control littermates

increased foot pigmentation ( J:90877 )

• the hind feet are darkly pigmented, unlike in control littermates

increased tail pigmentation ( J:90877 )

• the tail is darkly pigmented, unlike in control littermates

increased skin pigmentation ( J:90877 )

• when body hair is shaved, skin shows a dark bluish gray color in areas normally covered with hair, unlike in control littermates where skin is pink

• at 10-16 weeks of age, melanosis is noted in the dermal and epidermal layers of the skin of the neck, nose, tail, foot and external ear canal

abnormal brain meninges morphology ( J:90877 )

• at 10-16 weeks of age, pigmentation is noted in the dura mater (meninges)

• some hypercellularity is noted around the meningeal membranes

increased ear pigmentation ( J:90877 )

• the ears are darkly pigmented, unlike in control littermates

diluted coat color ( J:90877 )

• soon after birth, mice exhibit a light grayish brown (muted agouti) coat color

skin lesions ( J:90877 )

• at 3-5 weeks of age, mice exhibit nevi on the dorsal sides of the body

• at 10-16 weeks of age, lesions similar to blue nevi are frequently observed

increased foot pigmentation ( J:90877 )

• the hind feet are darkly pigmented, unlike in control littermates

increased tail pigmentation ( J:90877 )

• the tail is darkly pigmented, unlike in control littermates

increased skin pigmentation ( J:90877 )

• when body hair is shaved, skin shows a dark bluish gray color in areas normally covered with hair, unlike in control littermates where skin is pink

• at 10-16 weeks of age, melanosis is noted in the dermal and epidermal layers of the skin of the neck, nose, tail, foot and external ear canal

pigment incontinence ( J:90877 )

• mice show extensive deposition of melanin within the reticular dermis and upper dermal region

increased ear pigmentation ( J:90877 )

• the ears are darkly pigmented, unlike in control littermates

decreased body size ( J:90877 )

• mice are significantly smaller than control littermates

increased ear pigmentation ( J:90877 )

• the ears are darkly pigmented, unlike in control littermates

abnormal inner ear morphology ( J:90877 )

• mice exhibit abnormal inner ear tissue morphology, with obliteration of the bony structure

abnormal cochlea morphology ( J:90877 )

• the cochlear space contains an abnormal tissue mass composed of poorly differentiated spindle-to stellate cells in a loose myxomatous-like arrangement; many pigment-producing cells are found within the tissue mass

abnormal middle ear morphology ( J:90877 )

• mice exhibit abnormal middle ear tissue morphology

deafness ( J:90877 )

• mice appear to be deaf

circling ( J:90877 )

• when mice begin walking they often walk or run in circles

bidirectional circling ( J:90877 )

unidirectional circling ( J:90877 )

• although twirling is observed in both directions, each mouse circles primarily in one direction

abnormal choroid pigmentation ( J:90877 )

• at 10-16 weeks of age, uveal tissue is thickened and heavily pigmented

abnormal choroid melanocyte morphology ( J:90877 )

• heavily pigmented benign melanocytic lesions of the choroid are observed

abnormal eye anterior chamber morphology ( J:90877 )

• at 10-16 weeks of age, melanocytic lesions of the anterior chamber are observed

cataract ( J:90877 )

• at 10-16 weeks of age, mice exhibit cataracts

abnormal eyelid morphology ( J:90877 )

• at 10-16 weeks of age, eyelids appear enlarged and contain melanin

narrow eye opening ( J:90877 )

• mice never fully open their eyelids

increased tail pigmentation ( J:90877 )

• the tail is darkly pigmented, unlike in control littermates

increased ear pigmentation ( J:90877 )

• the ears are darkly pigmented, unlike in control littermates

neoplasm ( J:90877 )

N	• no spontaneous cutaneous melanomas are observed up to 48 weeks of age

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

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