mortality/aging
• mice do not survive more than a year compared to wild-type survival of 24 months to 38 months
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cardiovascular system
• relative to body weight
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• enlarged heart area
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• decrease in ventricular chamber dimensions
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• decrease in ventricular chamber dimensions
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• of the free walls
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muscle
• reduced cell area
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growth/size/body
• relative to body weight
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• enlarged heart area
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