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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mlkltm1.1Wsa
targeted mutation 1.1, Warren S Alexander
MGI:6251546
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Faddtm1Mpa/Faddtm1Mpa
Mlkltm1.1Wsa/Mlkltm1.1Wsa
Otulintm1c(EUCOMM)Hmgu/Otulintm1c(EUCOMM)Hmgu
Tg(KRT14-cre)1Cgn/0 		involves: C57BL/6 * C57BL/6N * DBA/2 MGI:7256619
cn2
 		Mlkltm1.1Wsa/Mlkltm1.1Wsa
Otulintm1c(EUCOMM)Hmgu/Otulintm1c(EUCOMM)Hmgu
Tg(KRT14-cre)1Cgn/0 		involves: C57BL/6 * C57BL/6N * DBA/2 MGI:7256622


Genotype
MGI:7256619
cn1
Allelic
Composition		 Faddtm1Mpa/Faddtm1Mpa
Mlkltm1.1Wsa/Mlkltm1.1Wsa
Otulintm1c(EUCOMM)Hmgu/Otulintm1c(EUCOMM)Hmgu
Tg(KRT14-cre)1Cgn/0
Genetic
Background		 involves: C57BL/6 * C57BL/6N * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Faddtm1Mpa mutation (0 available); any Fadd mutation (20 available)
Mlkltm1.1Wsa mutation (0 available); any Mlkl mutation (34 available)
Otulintm1c(EUCOMM)Hmgu mutation (0 available); any Otulin mutation (22 available)
Tg(KRT14-cre)1Cgn mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:312394 )
N
• normal circulating inflammatory cytokine levels

integument
integument phenotype ( J:312394 )
N
• no skin lesions and normal epidermal thickness




Genotype
MGI:7256622
cn2
Allelic
Composition		 Mlkltm1.1Wsa/Mlkltm1.1Wsa
Otulintm1c(EUCOMM)Hmgu/Otulintm1c(EUCOMM)Hmgu
Tg(KRT14-cre)1Cgn/0
Genetic
Background		 involves: C57BL/6 * C57BL/6N * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mlkltm1.1Wsa mutation (0 available); any Mlkl mutation (34 available)
Otulintm1c(EUCOMM)Hmgu mutation (0 available); any Otulin mutation (22 available)
Tg(KRT14-cre)1Cgn mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
dermatitis ( J:312394 )
• delineated inflamed skin lesions on back
• no skin lesions in tail

integument
integument phenotype ( J:312394 )
N
• no skin lesions and normal epidermal thickness in tail
dermatitis ( J:312394 )
• delineated inflamed skin lesions on back
• no skin lesions in tail




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory