All Phenotypes Rsph6a<em1Osb> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Rsph6a^em1Osb
endonuclease-mediated mutation 1, Osaka University
MGI:6241356

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rsph6a^em1Osb/Rsph6a^em1Osb	involves: C57BL/6NJcl * DBA/2NJcl	MGI:6241367

Allelic Composition	Rsph6a^em1Osb/Rsph6a^em1Osb
Genetic Background	involves: C57BL/6NJcl * DBA/2NJcl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rsph6a^em1Osb mutation (2 available); any Rsph6a mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

immotile sperm ( J:266136 )

• immotile sperm

abnormal spermatogenesis ( J:266136 )

• absence of elongated sperm tails (stage VII-VIII) in seminiferous tubules

• however, spermatogonia and spermatocyte development are comparable to controls

• retained elongated spermatids are frequently seen in stage IX tubules

abnormal sperm axoneme morphology ( J:266136 )

• axonemes with disrupted 9+2 patterns are seen in the mitochondrial sheath

abnormal sperm mitochondrial sheath morphology ( J:266136 )

• expression of TOMM20 is absent or mislocalized indicating disruption of mitochondrial sheath formation

abnormal sperm fibrous sheath morphology ( J:266136 )

• expression of CABYR is absent or uneven indicating a defect in fibrous sheath formation

short sperm flagellum ( J:266136 )

• average length is 24.6 +/- 22.9 um

abnormal sperm head morphology ( J:266136 )

• abnormal head shapes indicate impaired nuclear condensation

• club-shaped heads

abnormal manchette disassembly ( J:266136 )

• removal or caudal movement of manchettes is atypical

male infertility ( J:266136 )

• males form copulatory plugs but fail to sire litters

• males can produce viable offspring with intracytoplasmic sperm injection

cellular

abnormal sperm axoneme morphology ( J:266136 )

• axonemes with disrupted 9+2 patterns are seen in the mitochondrial sheath

abnormal sperm mitochondrial sheath morphology ( J:266136 )

• expression of TOMM20 is absent or mislocalized indicating disruption of mitochondrial sheath formation

abnormal sperm fibrous sheath morphology ( J:266136 )

• expression of CABYR is absent or uneven indicating a defect in fibrous sheath formation

short sperm flagellum ( J:266136 )

• average length is 24.6 +/- 22.9 um

abnormal sperm head morphology ( J:266136 )

• abnormal head shapes indicate impaired nuclear condensation

• club-shaped heads

abnormal manchette disassembly ( J:266136 )

• removal or caudal movement of manchettes is atypical

immotile sperm ( J:266136 )

• immotile sperm

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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