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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(ACTB-EGFP,-Kcnj8*Q53R*G343D)1Nich
transgene insertion 1, Colin G Nichols
MGI:6236321
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Tg(ACTB-EGFP,-Kcnj8*Q53R*G343D)1Nich/0
Tg(Myh11-icre/ERT2)1Soff/0 		involves: C57BL/6 * CBA * FVB/N MGI:6236324


Genotype
MGI:6236324
cn1
Allelic
Composition		 Tg(ACTB-EGFP,-Kcnj8*Q53R*G343D)1Nich/0
Tg(Myh11-icre/ERT2)1Soff/0
Genetic
Background		 involves: C57BL/6 * CBA * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(ACTB-EGFP,-Kcnj8*Q53R*G343D)1Nich mutation (0 available)
Tg(Myh11-icre/ERT2)1Soff mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
hypotension ( J:202037 )
• systolic and diastolic blood pressures are lower 3 weeks following tamoxifen induction
• however, heart rate is not affected




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory