About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Polr3aGt(LG04)Osb
gene trap (LG04), Research Institute for Microbial Diseases, Osaka University
MGI:6214817
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Polr3aGt(LG04)Osb/Polr3aGt(LG04)Osb B6;D2-Polr3aGt(LG04)Osb/OsbRbrc MGI:6214846
ht2
 		Polr3aGt(LG04)Osb/Polr3atm1Bebr involves: C57BL/6 * C57BL/6J * DBA/2 MGI:6214847


Genotype
MGI:6214846
hm1
Allelic
Composition		 Polr3aGt(LG04)Osb/Polr3aGt(LG04)Osb
Genetic
Background		 B6;D2-Polr3aGt(LG04)Osb/OsbRbrc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Polr3aGt(LG04)Osb mutation (0 available); any Polr3a mutation (70 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:6214847
ht2
Allelic
Composition		 Polr3aGt(LG04)Osb/Polr3atm1Bebr
Genetic
Background		 involves: C57BL/6 * C57BL/6J * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Polr3aGt(LG04)Osb mutation (0 available); any Polr3a mutation (70 available)
Polr3atm1Bebr mutation (0 available); any Polr3a mutation (70 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal gait ( J:250577 )
• mice exhibit a small, but significant, reduction in their back paw limb width at 270 days of age; this trend was seen at 365 days of age but is insignificant
• however, mice do not display other motor dysfunction at 1 year of age

nervous system
nervous system phenotype ( J:250577 )
N
• mice exhibit normal and complete myelination in the brain and cerebellum at 90 and 365 days of age and cerebellar morphology and Purkinje cell numbers are normal in 1 year old mice

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
NOT hypomyelinating leukodystrophy 7 DOID:0060794 OMIM:607694
 J:250577




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory