Phenotypes associated with this allele

• Allele Symbol: Polr3a^tm1Bebr
• Allele Name: targeted mutation 1, Bernard Brais
• Allele ID: MGI:6209824
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Polr3a^Gt(LG04)Osb/Polr3a^tm1Bebr	involves: C57BL/6 * C57BL/6J * DBA/2	MGI:6214847

Genotype
MGI:6214847

ht1

• Allelic Composition: Polr3a^Gt(LG04)Osb/Polr3a^tm1Bebr
• Genetic Background: involves: C57BL/6 * C57BL/6J * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal gait ( J:250577 )

• mice exhibit a small, but significant, reduction in their back paw limb width at 270 days of age; this trend was seen at 365 days of age but is insignificant

• however, mice do not display other motor dysfunction at 1 year of age

nervous system

nervous system phenotype ( J:250577 )

N • mice exhibit normal and complete myelination in the brain and cerebellum at 90 and 365 days of age and cerebellar morphology and Purkinje cell numbers are normal in 1 year old mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
NOT	hypomyelinating leukodystrophy 7	DOID:0060794	OMIM:607694	J:250577