Phenotypes associated with this allele

• Allele Symbol: Cep57^em2Jvd
• Allele Name: endonuclease-mediated mutation 2, Jan M A van Deursen
• Allele ID: MGI:6208812
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cep57^em2Jvd/Cep57^em2Jvd	involves: FVB/N	MGI:6208868
ht2	Cep57^em2Jvd/Cep57^+	involves: FVB/N	MGI:6208870
ht3	Cep57^em1Jvd/Cep57^em2Jvd	involves: 129 * C57BL/6 * FVB/N	MGI:6208871

Genotype
MGI:6208868

hm1

• Allelic Composition: Cep57^em2Jvd/Cep57^em2Jvd
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:264300 )

• fewer than expected mice are present at E13.5 with no mice alive at E15.5

embryonic lethality, incomplete penetrance ( J:264300 )

• fewer than expected mice are present at E13.5

Genotype
MGI:6208870

ht2

• Allelic Composition: Cep57^em2Jvd/Cep57⁺
• Genetic Background: involves: FVB/N

neoplasm

increased tumor incidence ( J:264300 )

• at 16 months of age

increased lung adenoma incidence ( J:264300 )

cellular

aneuploidy ( J:264300 )

• in splenocytes at 5 months of age

respiratory system

increased lung adenoma incidence ( J:264300 )

Genotype
MGI:6208871

ht3

• Allelic Composition: Cep57^em1Jvd/Cep57^em2Jvd
• Genetic Background: involves: 129 * C57BL/6 * FVB/N

cellular

abnormal cell morphology ( J:264300 )

• some mouse embryonic fibroblasts exhibit supernumerary centrioles at metaphase due to improper timing of centriole disengagement in mitosis