Phenotypes associated with this allele

• Allele Symbol: Notum^em150Sinn
• Allele Name: endonuclease-mediated mutation 150, Debora Sinner
• Allele ID: MGI:6200803
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Notum^em150Sinn/Notum^em150Sinn	Not Specified	MGI:6200804

Genotype
MGI:6200804

hm1

• Allelic Composition: Notum^em150Sinn/Notum^em150Sinn
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality ( J:260471 )

respiratory system

abnormal bronchus morphology ( J:260471 )

• bronchi have smaller luminal area

abnormal trachea morphology ( J:260471 )

abnormal tracheal smooth muscle morphology ( J:260471 )

• reduced trachealis muscle

abnormal trachea development ( J:260471 )

• abnormal morphology indicates ventralization of the tracheal mesenchyme

• decreased cell proliferation in the tracheal epithelium between E11.5 and E13.5

• impaired formation of mesenchymal condensations

abnormal tracheal cartilage morphology ( J:260471 )

• mispatterned cartilage that extends into the dorsal side of the trachea

• gaps in chondrogenesis are seen on the ventral aspect of the trachea

decreased tracheal cartilage ring number ( J:260471 )

trachea stenosis ( J:260471 )

renal/urinary system

abnormal kidney development ( J:260471 )

muscle

abnormal tracheal smooth muscle morphology ( J:260471 )

• reduced trachealis muscle

skeleton

abnormal tracheal cartilage morphology ( J:260471 )

• mispatterned cartilage that extends into the dorsal side of the trachea

• gaps in chondrogenesis are seen on the ventral aspect of the trachea

decreased tracheal cartilage ring number ( J:260471 )