About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ly96m1Btlr
mutation 1, Bruce Beutler
MGI:6200370
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ly96m1Btlr/Ly96m1Btlr C57BL/6J-Ly96m1Btlr MGI:6200372


Genotype
MGI:6200372
hm1
Allelic
Composition		 Ly96m1Btlr/Ly96m1Btlr
Genetic
Background		 C57BL/6J-Ly96m1Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ly96m1Btlr mutation (0 available); any Ly96 mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased macrophage apoptosis ( J:265259 )
• decrease in LPS-induced macrophage necroptosis
decreased interleukin-1 beta secretion ( J:265259 )
• peritoneal macrophages isolated from pique homozygous mice secreted reduced amounts of the proinflammatory cytokine interleukin (IL)-1beta in response to priming with lipopolysaccharide (LPS) followed bynigericin treatment
decreased tumor necrosis factor secretion ( J:265259 )
• from macrophages in response to the Toll-like receptor 4 (TLR4) ligand, lipolysaccharide (LPS)

cellular
decreased macrophage apoptosis ( J:265259 )
• decrease in LPS-induced macrophage necroptosis

hematopoietic system
decreased macrophage apoptosis ( J:265259 )
• decrease in LPS-induced macrophage necroptosis




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory