Phenotypes associated with this allele

• Allele Symbol: Ikzf1^m1Btlr
• Allele Name: mutation 1, Bruce Beutler
• Allele ID: MGI:6200316
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ikzf1^m1Btlr/Ikzf1^m1Btlr	C57BL/6J-Ikzf1^m1Btlr	MGI:6200318

Genotype
MGI:6200318

hm1

• Allelic Composition: Ikzf1^m1Btlr/Ikzf1^m1Btlr
• Genetic Background: C57BL/6J-Ikzf1^m1Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased B-1 B cell number ( J:265249 )

decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:265249 )

decreased CD8-positive, naive alpha-beta T cell number ( J:265249 )

increased T cell number ( J:265249 )

increased CD4-positive, alpha-beta T cell number ( J:265249 )

increased central memory CD4-positive, alpha-beta T cell number ( J:265249 )

increased effector memory CD4-positive, alpha-beta T cell number ( J:265249 )

increased CD8-positive, alpha-beta T cell number ( J:265249 )

increased central memory CD8 positive, alpha-beta T cell number ( J:265249 )

increased single-positive T cell number ( J:265249 )

increased IgG level ( J:265249 )

• increased T-dependent antibody responses to ovalbumin administered with aluminum hydroxide

abnormal natural killer cell mediated cytotoxicity ( J:265249 )

enhanced humoral immune response ( J:265249 )

• increased T-dependent antibody responses to ovalbumin administered with aluminum hydroxide

increased response to antigen ( J:265249 )

• increased T-dependent antibody responses to ovalbumin administered with aluminum hydroxide

cardiovascular system

decreased heart rate ( J:265249 )

hematopoietic system

increased B-1 B cell number ( J:265249 )

decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:265249 )

decreased CD8-positive, naive alpha-beta T cell number ( J:265249 )

increased T cell number ( J:265249 )

increased CD4-positive, alpha-beta T cell number ( J:265249 )

increased central memory CD4-positive, alpha-beta T cell number ( J:265249 )

increased effector memory CD4-positive, alpha-beta T cell number ( J:265249 )

increased CD8-positive, alpha-beta T cell number ( J:265249 )

increased central memory CD8 positive, alpha-beta T cell number ( J:265249 )

increased single-positive T cell number ( J:265249 )

increased IgG level ( J:265249 )

• increased T-dependent antibody responses to ovalbumin administered with aluminum hydroxide

abnormal natural killer cell mediated cytotoxicity ( J:265249 )