About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Stk4m1Btlr
mutation 4, Bruce Beutler
MGI:6200285
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Stk4m1Btlr/Stk4m1Btlr C57BL/6J-Stk4m1Btlr MGI:6200287


Genotype
MGI:6200287
hm1
Allelic
Composition		 Stk4m1Btlr/Stk4m1Btlr
Genetic
Background		 C57BL/6J-Stk4m1Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stk4m1Btlr mutation (0 available); any Stk4 mutation (72 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased IgD level ( J:265233 )
• on the surface of peripheral blood B cells
increased IgE level ( J:265233 )
• total IgE in the serum was increased as well as OVA-specific IgE after OVA/Alum challenge
increased IgM level ( J:265233 )
• diminished T-dependent antibody response to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal) was diminished

immune system
abnormal humoral immune response ( J:265233 )
• diminished T-dependent antibody response to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal) was diminished
decreased IgD level ( J:265233 )
• on the surface of peripheral blood B cells
increased IgE level ( J:265233 )
• total IgE in the serum was increased as well as OVA-specific IgE after OVA/Alum challenge
increased IgM level ( J:265233 )
• diminished T-dependent antibody response to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal) was diminished




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory