Phenotypes associated with this allele

• Allele Symbol: Nlrp1a^m2Btlr
• Allele Name: mutation2, Bruce Beutler
• Allele ID: MGI:6200053
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nlrp1a^m2Btlr/Nlrp1a^m2Btlr	C57BL/6J-Nlrp1a^m2Btlr	MGI:6200056

Genotype
MGI:6200056

hm1

• Allelic Composition: Nlrp1a^m2Btlr/Nlrp1a^m2Btlr
• Genetic Background: C57BL/6J-Nlrp1a^m2Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased macrophage apoptosis ( J:265174 )

• in response to LPS was increased

increased neutrophil cell number ( J:265174 )

increased dendritic cell number ( J:265174 )

decreased B cell number ( J:265174 )

• of B cells and IgM+ B cells in the peripheral blood

decreased NK cell number ( J:265174 )

decreased interleukin-1 beta secretion ( J:265174 )

• impaired peritoneal macrophage NLRC4 inflammasome responses, marked by decreased secretion of the proinflammatory cytokine interleukin (IL)-1beta in response to priming with flagellin

homeostasis/metabolism

hypoglycemia ( J:265174 )

• fasting

cellular

increased macrophage apoptosis ( J:265174 )

• in response to LPS was increased

hematopoietic system

increased macrophage apoptosis ( J:265174 )

• in response to LPS was increased

increased neutrophil cell number ( J:265174 )

increased dendritic cell number ( J:265174 )

decreased B cell number ( J:265174 )

• of B cells and IgM+ B cells in the peripheral blood

decreased NK cell number ( J:265174 )