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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nlrp1am1Btlr
mutation 1, Bruce Beutler
MGI:6200049
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Nlrp1am1Btlr/Nlrp1am1Btlr C57BL/6J-Nlrp1am1Btlr MGI:6200051


Genotype
MGI:6200051
hm1
Allelic
Composition		 Nlrp1am1Btlr/Nlrp1am1Btlr
Genetic
Background		 C57BL/6J-Nlrp1am1Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlrp1am1Btlr mutation (0 available); any Nlrp1a mutation (64 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased macrophage apoptosis ( J:265173 )
• in response to LPS was increased
decreased B cell number ( J:265173 )
• of B cells, IgD+ B cells, and IgM+ B cells in the peripheral blood
increased IgE level ( J:265173 )
• in the serum
increased tumor necrosis factor secretion ( J:265173 )
• in response to the TLR7 ligand R848

growth/size/body
decreased body weight ( J:265173 )

cellular
increased macrophage apoptosis ( J:265173 )
• in response to LPS was increased

hematopoietic system
increased macrophage apoptosis ( J:265173 )
• in response to LPS was increased
decreased B cell number ( J:265173 )
• of B cells, IgD+ B cells, and IgM+ B cells in the peripheral blood
increased IgE level ( J:265173 )
• in the serum




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory