About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nlrp1am1Btlr
mutation 1, Bruce Beutler
MGI:6200049
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Nlrp1am1Btlr/Nlrp1am1Btlr C57BL/6J-Nlrp1am1Btlr MGI:6200051


Genotype
MGI:6200051
hm1
Allelic
Composition		 Nlrp1am1Btlr/Nlrp1am1Btlr
Genetic
Background		 C57BL/6J-Nlrp1am1Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlrp1am1Btlr mutation (0 available); any Nlrp1a mutation (64 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased macrophage apoptosis ( J:265173 )
• in response to LPS was increased
decreased B cell number ( J:265173 )
• of B cells, IgD+ B cells, and IgM+ B cells in the peripheral blood
increased IgE level ( J:265173 )
• in the serum
increased tumor necrosis factor secretion ( J:265173 )
• in response to the TLR7 ligand R848

growth/size/body
decreased body weight ( J:265173 )

cellular
increased macrophage apoptosis ( J:265173 )
• in response to LPS was increased

hematopoietic system
increased macrophage apoptosis ( J:265173 )
• in response to LPS was increased
decreased B cell number ( J:265173 )
• of B cells, IgD+ B cells, and IgM+ B cells in the peripheral blood
increased IgE level ( J:265173 )
• in the serum




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory