Phenotypes associated with this allele

• Allele Symbol: Rasgrp1^m1Btlr
• Allele Name: mutation 1, Bruce Beutler
• Allele ID: MGI:6200006
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rasgrp1^m1Btlr/Rasgrp1^m1Btlr	C57BL/6J-Rasgrp1^m1Btlr	MGI:6200008

Genotype
MGI:6200008

hm1

• Allelic Composition: Rasgrp1^m1Btlr/Rasgrp1^m1Btlr
• Genetic Background: C57BL/6J-Rasgrp1^m1Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

increased NK cell number ( J:265163 )

decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:265163 )

increased effector memory CD4-positive, alpha-beta T cell number ( J:265163 )

increased CD8-positive, alpha-beta memory T cell number ( J:265163 )

decreased CD8-positive, naive alpha-beta T cell number ( J:265163 )

increased IgA level ( J:265163 )

• in response to challenge with ovalbumin administered with aluminum hydroxide (OVA/Alum)

increased IgE level ( J:265163 )

decreased IgM level ( J:265163 )

• diminished T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll)

increased IgM level ( J:265163 )

• diminished T-dependent antibody responses to ovalbumin administered with aluminum hydroxide and to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal)

immune system

increased NK cell number ( J:265163 )

decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:265163 )

increased effector memory CD4-positive, alpha-beta T cell number ( J:265163 )

increased CD8-positive, alpha-beta memory T cell number ( J:265163 )

decreased CD8-positive, naive alpha-beta T cell number ( J:265163 )

abnormal humoral immune response ( J:265163 )

• diminished T-dependent antibody responses to ovalbumin administered with aluminum hydroxide and to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal)

• diminished T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll)

increased IgA level ( J:265163 )

• in response to challenge with ovalbumin administered with aluminum hydroxide (OVA/Alum)

increased IgE level ( J:265163 )

decreased IgM level ( J:265163 )

• diminished T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll)

increased IgM level ( J:265163 )

• diminished T-dependent antibody responses to ovalbumin administered with aluminum hydroxide and to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal)