Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zfp462Tn(pb-Act-RFP)1.090115023-HRAZhu mutation
(0 available);
any
Zfp462 mutation
(336 available)
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mortality/aging
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• no surviving mice are found postnatally
• dying homozygotes are found at E18.5
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growth/size/body
vision/eye
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zfp462Tn(pb-Act-RFP)1.090115023-HRAZhu mutation
(0 available);
any
Zfp462 mutation
(336 available)
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behavior/neurological
N |
• no defects in memory or movement
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• spend more time in the closed arm of an elevated plus maze
• in an open field test mice spend less time in the inside area and have fewer center entries
• spend less time in the light compartment and make fewer light-dark transitions in a light-dark box test
• bury more marbles in a marble burying assay
• treatment with imipramine attenuates anxiety-like behaviors
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• increased grooming time and number of grooming bouts
• treatment with imipramine attenuates excessive self-grooming
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nervous system
integument
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• hair loss that is aggravated with age with 15% and 30% of mice showing hair loss at 4 and 6 months of age
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growth/size/body
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• from P1 to 2 months of age
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• delayed growth from P1 to 2 months of age
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