Phenotypes associated with this allele

• Allele Symbol: Zfp462^{Tn(pb-Act-RFP)1.090115023-HRAZhu}
• Allele Name: transposon insertion 1.090115023-HRA, Yuan Zhuang
• Allele ID: MGI:6198748
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Zfp462^Tn(pb-Act-RFP)1.090115023-HRAZhu/Zfp462^Tn(pb-Act-RFP)1.090115023-HRAZhu	involves: FVB/N	MGI:6198751
ht2	Zfp462^Tn(pb-Act-RFP)1.090115023-HRAZhu/Zfp462^+	involves: FVB/N	MGI:6198752

Genotype
MGI:6198751

hm1

• Allelic Composition: Zfp462^{Tn(pb-Act-RFP)1.090115023-HRAZhu}/Zfp462^{Tn(pb-Act-RFP)1.090115023-HRAZhu}
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:262219 )

• no surviving mice are found postnatally

• dying homozygotes are found at E18.5

growth/size/body

decreased birth body size ( J:262219 )

• at E18.5

vision/eye

eyelids open at birth ( J:262219 )

Genotype
MGI:6198752

ht2

• Allelic Composition: Zfp462^{Tn(pb-Act-RFP)1.090115023-HRAZhu}/Zfp462⁺
• Genetic Background: involves: FVB/N

behavior/neurological

behavior/neurological phenotype ( J:262219 )

N • no defects in memory or movement

increased anxiety-related response ( J:262219 )

• spend more time in the closed arm of an elevated plus maze

• in an open field test mice spend less time in the inside area and have fewer center entries

• spend less time in the light compartment and make fewer light-dark transitions in a light-dark box test

• bury more marbles in a marble burying assay

• treatment with imipramine attenuates anxiety-like behaviors

increased grooming behavior ( J:262219 )

• increased grooming time and number of grooming bouts

• treatment with imipramine attenuates excessive self-grooming

nervous system

decreased brain weight ( J:262219 )

integument

alopecia ( J:262219 )

• hair loss that is aggravated with age with 15% and 30% of mice showing hair loss at 4 and 6 months of age

growth/size/body

decreased body weight ( J:262219 )

• from P1 to 2 months of age

postnatal growth retardation ( J:262219 )

• delayed growth from P1 to 2 months of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
generalized anxiety disorder		DOID:14320		J:262219