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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Vkorc1tm1.1Kry
targeted mutation 1.1, Gerard Karsenty
MGI:6198560
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Vkorc1tm1.1Kry/Vkorc1tm1.1Kry
Tg(BGLAP-cre)1Clem/0 		involves: FVB/NJ MGI:6198744
cn2
 		Vkorc1tm1.1Kry/Vkorc1tm1.1Kry
Vkorc1l1tm1.1Kry/Vkorc1l1tm1.1Kry
Tg(BGLAP-cre)1Clem/0 		involves: FVB/NJ MGI:6198758


Genotype
MGI:6198744
cn1
Allelic
Composition		 Vkorc1tm1.1Kry/Vkorc1tm1.1Kry
Tg(BGLAP-cre)1Clem/0
Genetic
Background		 involves: FVB/NJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(BGLAP-cre)1Clem mutation (1 available)
Vkorc1tm1.1Kry mutation (0 available); any Vkorc1 mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
homeostasis/metabolism phenotype ( J:264734 )
N
• slight but not significant improvement in glucose tolerance
abnormal circulating osteocalcin level ( J:264734 )
• decreased GLA-OCN, further upon prevention of coprophagy
• 10-fold increase in GLU-OCN levels
• however, total OCN levels are normal

hematopoietic system
hematopoietic system phenotype ( J:264734 )
N
• unlike in null mice, no hemostatic defects were detected




Genotype
MGI:6198758
cn2
Allelic
Composition		 Vkorc1tm1.1Kry/Vkorc1tm1.1Kry
Vkorc1l1tm1.1Kry/Vkorc1l1tm1.1Kry
Tg(BGLAP-cre)1Clem/0
Genetic
Background		 involves: FVB/NJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(BGLAP-cre)1Clem mutation (1 available)
Vkorc1l1tm1.1Kry mutation (0 available); any Vkorc1l1 mutation (21 available)
Vkorc1tm1.1Kry mutation (0 available); any Vkorc1 mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal circulating osteocalcin level ( J:264734 )
• increase in GLU-OCN levels as in mice with wild-type Vkorc1l1




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory