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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ggcxtm1.1Kry
targeted mutation 1.1, Gerard Karsenty
MGI:6198558
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Del(3Bglap2-Bglap)2Kry/+
Ggcxtm1.1Kry/Ggcxtm1.1Kry
Tg(BGLAP-cre)1Clem/0 		involves: 129S7/SvEvBrd * FVB/NJ MGI:6198739
cn2
 		Ggcxtm1.1Kry/Ggcxtm1.1Kry
Tg(Col1a1-cre)1Kry/0 		involves: FVB/N MGI:6198735
cn3
 		Ggcxtm1.1Kry/Ggcxtm1.1Kry
Tg(BGLAP-cre)1Clem/0 		involves: FVB/NJ MGI:6198737


Genotype
MGI:6198739
cn1
Allelic
Composition		 Del(3Bglap2-Bglap)2Kry/+
Ggcxtm1.1Kry/Ggcxtm1.1Kry
Tg(BGLAP-cre)1Clem/0
Genetic
Background		 involves: 129S7/SvEvBrd * FVB/NJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(3Bglap2-Bglap)2Kry mutation (0 available); any Del(3Bglap2-Bglap)2Kry mutation (0 available)
Ggcxtm1.1Kry mutation (0 available); any Ggcx mutation (36 available)
Tg(BGLAP-cre)1Clem mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
homeostasis/metabolism phenotype ( J:264734 )
N
• glucose tolerance is normal




Genotype
MGI:6198735
cn2
Allelic
Composition		 Ggcxtm1.1Kry/Ggcxtm1.1Kry
Tg(Col1a1-cre)1Kry/0
Genetic
Background		 involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ggcxtm1.1Kry mutation (0 available); any Ggcx mutation (36 available)
Tg(Col1a1-cre)1Kry mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:264734 )
N
• mice do not exhibit hypergonadism with normal sperm count, testis weight, epididymis weight, and seminal vesicle weight

homeostasis/metabolism
hypoglycemia ( J:264734 )
• in fasted mice fed a high-fat diet
abnormal circulating osteocalcin level ( J:264734 )
• increased levels of GLU-OCN 3 to 4 times
• however, total and GLA-OCN levels are normal
improved glucose tolerance ( J:264734 )
• in female and male mice when fed a high-fat diet or a normal diet
increased insulin sensitivity ( J:264734 )
• in female and male mice when fed a high-fat diet or a normal diet
• however, hyperinsulinemia when fed a high-fat diet is normal

growth/size/body
decreased susceptibility to diet-induced obesity ( J:264734 )
• when fed a high-fat diet
thin body ( J:264734 )

adipose tissue




Genotype
MGI:6198737
cn3
Allelic
Composition		 Ggcxtm1.1Kry/Ggcxtm1.1Kry
Tg(BGLAP-cre)1Clem/0
Genetic
Background		 involves: FVB/NJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ggcxtm1.1Kry mutation (0 available); any Ggcx mutation (36 available)
Tg(BGLAP-cre)1Clem mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:264734 )
N
• mice do not exhibit hypergonadism with normal sperm count, testis weight, epididymis weight, and seminal vesicle weight

homeostasis/metabolism
decreased circulating osteocalcin level ( J:264734 )
• GLA-OCN and total OCN levels decreased 75 and 10 times, respectively

skeleton
skeleton phenotype ( J:264734 )
N
• mice exhibit normal trabecular and cortical bone density, numbers of osteoblast and osteoblasts, bone formation rates and osteoclastic activity




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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory