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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Trem2em2Bwef
endonuclease-mediated mutation 2, Benedikt Wefers
MGI:6197715
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Trem2em2Bwef/Trem2em2Bwef involves: C57BL/6J * DBA/2J * FVB/N MGI:5904595
ht2
 		Trem2em2Bwef/Trem2+ involves: C57BL/6J * DBA/2J * FVB/N MGI:5904596


Genotype
MGI:5904595
hm1
Allelic
Composition		 Trem2em2Bwef/Trem2em2Bwef
Genetic
Background		 involves: C57BL/6J * DBA/2J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trem2em2Bwef mutation (0 available); any Trem2 mutation (65 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased macrophage apoptosis ( J:242126 )
• in bone marrow-derived macrophages
decreased macrophage proliferation ( J:242126 )
• in bone marrow-derived macrophages
impaired macrophage phagocytosis ( J:242126 )
• of E. coli or fibrillar Abeta1-42 in bone marrow-derived macrophages
decreased macrophage cell number ( J:242126 )
• fewer macrophages are produced from bone marrow cells stimulated with colony-stimulating factor compared with wild-type cells
decreased microglial cell activation ( J:242126 )
• age-dependent decrease in activity at 12 months of age
increased circulating interleukin-6 level ( J:242126 )
• following LPS-stimulation
increased susceptibility to endotoxin shock ( J:242126 )
• LPS-treated mice exhibit increased IL6, TNFa and CCL2 serum levels compared with wild-type mice

nervous system
decreased microglial cell activation ( J:242126 )
• age-dependent decrease in activity at 12 months of age

cardiovascular system
abnormal blood volume ( J:242126 )
• reduced brain perfusion at 6 months of age

cellular
increased macrophage apoptosis ( J:242126 )
• in bone marrow-derived macrophages
decreased macrophage proliferation ( J:242126 )
• in bone marrow-derived macrophages
impaired macrophage phagocytosis ( J:242126 )
• of E. coli or fibrillar Abeta1-42 in bone marrow-derived macrophages

hematopoietic system
increased macrophage apoptosis ( J:242126 )
• in bone marrow-derived macrophages
decreased macrophage proliferation ( J:242126 )
• in bone marrow-derived macrophages
impaired macrophage phagocytosis ( J:242126 )
• of E. coli or fibrillar Abeta1-42 in bone marrow-derived macrophages
decreased macrophage cell number ( J:242126 )
• fewer macrophages are produced from bone marrow cells stimulated with colony-stimulating factor compared with wild-type cells
decreased microglial cell activation ( J:242126 )
• age-dependent decrease in activity at 12 months of age

homeostasis/metabolism
increased circulating interleukin-6 level ( J:242126 )
• following LPS-stimulation
abnormal glucose homeostasis ( J:242126 )
• reduced cerebral glucose metabolism
• however, blood glucose levels are normal

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
frontotemporal dementia DOID:9255 OMIM:600274
 J:242126




Genotype
MGI:5904596
ht2
Allelic
Composition		 Trem2em2Bwef/Trem2+
Genetic
Background		 involves: C57BL/6J * DBA/2J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trem2em2Bwef mutation (0 available); any Trem2 mutation (65 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased macrophage cell number ( J:242126 )
• fewer macrophages are produced from bone marrow cells stimulated with colony-stimulating factor

immune system
decreased macrophage cell number ( J:242126 )
• fewer macrophages are produced from bone marrow cells stimulated with colony-stimulating factor




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory