Phenotypes associated with this allele

• Allele Symbol: Pnpla3^tm1.1Hobb
• Allele Name: targeted mutation 1.1, Helen H Hobbs
• Allele ID: MGI:6197539
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pnpla3^tm1.1Hobb/Pnpla3^tm1.1Hobb	involves: 129 * C57BL/6J	MGI:6197545
ht2	Pnpla3^tm1.1Hobb/Pnpla3^+	involves: 129 * C57BL/6J	MGI:6197542

Genotype
MGI:6197545

hm1

• Allelic Composition: Pnpla3^tm1.1Hobb/Pnpla3^tm1.1Hobb
• Genetic Background: involves: 129 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

abnormal fat cell morphology ( J:264475 )

• increase in the number of large, Oil Red O+ lipid droplets in the livers of mice fed a high-sucrose diet

homeostasis/metabolism

increased fatty acids level ( J:264475 )

• palmitoleate and linoleate are slightly higher in liver triglyceride fraction of mice

increased liver triglyceride level ( J:264475 )

• mice exhibit an increase in hepatic triglyceride content after 4 weeks on a high-sucrose diet

liver/biliary system

increased liver triglyceride level ( J:264475 )

• mice exhibit an increase in hepatic triglyceride content after 4 weeks on a high-sucrose diet

hepatic steatosis ( J:264475 )

• mice develop fatty liver when fed a high-sucrose or high-fat diet

Genotype
MGI:6197542

ht2

• Allelic Composition: Pnpla3^tm1.1Hobb/Pnpla3⁺
• Genetic Background: involves: 129 * C57BL/6J

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:264475 )

N • levels of triglycerides, phosphatidylcholine, cholesteryl esters and free cholesterol in the livers of females fed a chow diet or a high-sucrose diet are normal

N • lipid levels in the liver and plasma are normal on a chow diet

N • circulating liver enzymes or plasma lipids are normal on a high-sucrose diet