Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ythdc1tm1.2Jw mutation
(0 available);
any
Ythdc1 mutation
(51 available)
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mortality/aging
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• no mice are present at E11.5 with only 1 (out of 9 embryos) present at E8.5
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Ddx4-cre)1Dcas mutation
(2 available)
Ythdc1tm1.1Jw mutation
(1 available);
any
Ythdc1 mutation
(51 available)
Ythdc1tm1.2Jw mutation
(0 available);
any
Ythdc1 mutation
(51 available)
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reproductive system
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• oocytes contain cytoplasmic RNA granules unlike in oocytes from control mice
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• at 6 months of age and beyond
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• lack of germ cells at PND25 and in adult male mice
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• fewer spermatogonia in seminiferous tubules at PND8 compared with control mice
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• ovaries lack secondary follicles
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• ovaries lack antral follicles
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• blocked at the primary follicle stage
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endocrine/exocrine glands
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• ovaries lack secondary follicles
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• ovaries lack antral follicles
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• blocked at the primary follicle stage
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cellular
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• oocytes contain cytoplasmic RNA granules unlike in oocytes from control mice
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• at 6 months of age and beyond
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• lack of germ cells at PND25 and in adult male mice
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• fewer spermatogonia in seminiferous tubules at PND8 compared with control mice
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• oocytes exhibit widespread m6A-dependent-splicing defects and extensive alternative polyadenylation
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Zp3-cre)93Knw mutation
(2 available)
Ythdc1tm1.1Jw mutation
(1 available);
any
Ythdc1 mutation
(51 available)
Ythdc1tm1.2Jw mutation
(0 available);
any
Ythdc1 mutation
(51 available)
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reproductive system
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• blocked at the primary follicle stage
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endocrine/exocrine glands
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• blocked at the primary follicle stage
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