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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Lsm3em1Caox
endonuclease-mediated mutation 1, Xuetao Cao
MGI:6194617
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Lsm3em1Caox/Lsm3em1Caox involves: C57BL/6J MGI:6194662


Genotype
MGI:6194662
hm1
Allelic
Composition		 Lsm3em1Caox/Lsm3em1Caox
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lsm3em1Caox mutation (0 available); any Lsm3 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased susceptibility to Riboviria infection induced morbidity/mortality ( J:262834 )
• following infection of vesicular stomatitis virus with a high dose

immune system
increased circulating interferon-alpha level ( J:262834 )
• following infection of vesicular stomatitis virus with a high dose
increased circulating interferon-beta level ( J:262834 )
• following infection of vesicular stomatitis virus with a high dose
• following infection with influenza virus strain A/Puerto Rico/8/1981
increased circulating interleukin-6 level ( J:262834 )
• following infection with influenza virus strain A/Puerto Rico/8/1981
decreased susceptibility to Riboviria infection ( J:262834 )
• following infection of vesicular stomatitis virus with a moderate dose, mice exhibit increased serum alpha and beta interferon, reduced viral burden, reduced severity of pulmonary inflammation, and decreased mortality compared with wild-type mice
decreased susceptibility to Riboviria infection induced morbidity/mortality ( J:262834 )
• following infection of vesicular stomatitis virus with a high dose
decreased susceptibility to Orthomyxoviridae infection ( J:262834 )
• mice infected with influenza virus strain A/Puerto Rico/8/1981 exhibit higher levels of FBN-beta and IL6 compared with wild-type mice

homeostasis/metabolism
increased circulating interferon-alpha level ( J:262834 )
• following infection of vesicular stomatitis virus with a high dose
increased circulating interferon-beta level ( J:262834 )
• following infection of vesicular stomatitis virus with a high dose
• following infection with influenza virus strain A/Puerto Rico/8/1981
increased circulating interleukin-6 level ( J:262834 )
• following infection with influenza virus strain A/Puerto Rico/8/1981




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/07/2024
MGI 6.23 		The Jackson Laboratory