Phenotypes associated with this allele

• Allele Symbol: Mtln^em1Rlbd
• Allele Name: endonuclease-mediated mutation 1, Ryan L Boudreau
• Allele ID: MGI:6191656
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mtln^em1Rlbd/Mtln^em1Rlbd	involves: C57BL/6J * SJL/J	MGI:6191660

Genotype
MGI:6191660

hm1

• Allelic Composition: Mtln^em1Rlbd/Mtln^em1Rlbd
• Genetic Background: involves: C57BL/6J * SJL/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal oxidative phosphorylation ( J:263464 )

• cardiac and skeletal muscles exhibit reduced CI activities compared with wild-type mice

decreased fatty acid beta-oxidation ( J:263464 )

• skeletal muscle and left ventricular fibers from fasted mice exhibit lower rate of maximal fatty acid oxidation compared with wild-type mice

cardiovascular system

abnormal cardiac muscle tissue morphology ( J:263464 )

• left ventricular fibers exhibit reduced mitochondrial calcium retention capacity compared with wild-type mice

homeostasis/metabolism

decreased fatty acid beta-oxidation ( J:263464 )

• skeletal muscle and left ventricular fibers from fasted mice exhibit lower rate of maximal fatty acid oxidation compared with wild-type mice

muscle

abnormal cardiac muscle tissue morphology ( J:263464 )

• left ventricular fibers exhibit reduced mitochondrial calcium retention capacity compared with wild-type mice