Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fechtm1.1(FECH*)Emi mutation
(1 available);
any
Fech mutation
(24 available)
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mortality/aging
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• no live mice are born and while embryos are evident at E11, only remnants of embryos are seen at E13, indicating lethality after E11 but before E13
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growth/size/body
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• E11 embryos are smaller
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embryo
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• E11 embryos are smaller
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mortality/aging
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• fewer than the expected numbers of mice are obtained indicating prenatal mortality
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growth/size/body
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• reduced body size and mass which is already seen shortly after birth becomes more pronounced with age
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• increase in liver mass is more pronounced than in homozygous Fechtm1Pas mice
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• increase in spleen mass is more pronounced than in homozygous Fechtm1Pas mice
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hematopoietic system
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• increase in spleen mass is more pronounced than in homozygous Fechtm1Pas mice
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• red blood cell counts are reduced
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homeostasis/metabolism
immune system
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• increase in spleen mass is more pronounced than in homozygous Fechtm1Pas mice
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integument
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• mice exhibit skin photosensitivity, with all tested light doses eliciting acute symptoms on the exposed skin of erythema, orange exudate, and mice showing behavioral changes indicative of pain (hunched posture, reduced movement, occasional shivering, closed eyes and drawn back ears)
• pain symptoms disappear by 24 hours but the morphological changes persist for several days
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liver/biliary system
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• liver tissue appears more rigid upon palpation compared with the usual soft texture
• hepatobiliary pathology in livers, with an increase in small cells, presumably macrophages, in the liver
• many brown pigment granules are present in biliary canaliculi and portal macrophages, probably representing protoporphyrin IX deposits
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• increase in liver mass is more pronounced than in homozygous Fechtm1Pas mice
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• many brown pigment granules are present in biliary canaliculi
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• yellowish tint of the dermis, muscles and internal organs
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