Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scyl3tm1.1Spel mutation
(0 available);
any
Scyl3 mutation
(32 available)
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muscle
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• angulated muscle fibers in rectus femoris
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behavior/neurological
N |
• mice exhibit normal gripe strength in a mesh test at 4 and 8 weeks of age
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immune system
N |
• mice exhibit normal T- and B-cell development and homeostasis
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cellular
N |
• mouse embryonic fibroblasts exhibit normal migration in vitro and proliferation
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scyl1tm1.1Spel mutation
(0 available);
any
Scyl1 mutation
(21 available)
Scyl3tm1.1Spel mutation
(0 available);
any
Scyl3 mutation
(32 available)
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nervous system
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• in the ventral horn of the spinal cord to a greater extent than in Scyl1tm1.1Spel single homozygotes
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• of large motor neurons in the ventral horn of the spinal cord at 4 weeks compared with Scyl1tm1.1Spel single homozygotes
• at 8 weeks compared with wild-type mice
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• at 4 and 8 weeks with Tardbp pathology
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• reduced number of large caliber axons and total number of myelinated fibers in the sciatic nerve at 4 weeks of age
• at 8 weeks compared with wild-type mice
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• reduced total number of myelinated fibers in the sciatic nerve at 4 weeks of age
• at 8 weeks compared with wild-type mice
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growth/size/body
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• compared with either single homozygotes
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• at 8 weeks compared with Scyl1tm1.1Spel single homozygotes
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behavior/neurological
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• progressive motor dysfunction leading to a paralysis that is worse than in Scyl1tm1.1Spel single homozygotes at the same age
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• progressive motor dysfunction leading to a paralysis that is worse than in Scyl1tm1.1Spel single homozygotes at the same age
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muscle
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• reduced cross-sectional area in rectus femoris and bicep brachii at 4 and 8 weeks of age that is more severe at 4 weeks than in Scyl1tm1.1Spel single homozygotes
• at 8 weeks compared with wild-type mice
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