Phenotypes associated with this allele

• Allele Symbol: Tg(Fabp4-LMNA*R482Q)#Hjw
• Allele Name: transgene insertion, Howard J Worman
• Allele ID: MGI:6188858
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Fabp4-LMNA*R482Q)#Hjw/0	FVB.Cg-Tg(Fabp4-LMNA*R482Q)#Hjw	MGI:6188860

Genotype
MGI:6188860

tg1

• Allelic Composition: Tg(Fabp4-LMNA*R482Q)#Hjw/0
• Genetic Background: FVB.Cg-Tg(Fabp4-LMNA*R482Q)#Hjw

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

abnormal adipose tissue morphology ( J:237920 )

• mice show altered extracellular matrix and fibrosis in subcutaneous and visceral adipose tissue

• however, mice do not develop gross anatomic or metabolic signs of partial lipodystrophy, and mice fed a high-fat diet for 28 weeks do not show differences in the ratios of adipose tissue mass to total body mass, in plasma cholesterol, triglycerides, or free fatty acid concentrations, and only an insignificant trend toward impaired glucose tolerance

abnormal fat cell morphology ( J:237920 )

• adipocyte surface area is smaller in subcutaneous adipose tissue

• adipocyte surface area is larger in parametrial adipose tissue

abnormal parametrial fat pad morphology ( J:237920 )

• adipocyte surface area is larger in parametrial adipose tissue

• parametrial adipose tissue shows altered extracellular matrix and fibrosis

homeostasis/metabolism

increased collagen level ( J:237920 )

• subcutaneous and parametrial adipose tissue shows an increase in Sirius red staining of collagen fibrils, indicating increased collagen in relation to fat

integument

abnormal hypodermis morphology ( J:237920 )

• adipocyte surface area is smaller in subcutaneous adipose tissue

• subcutaneous adipose tissue shows altered extracellular matrix and fibrosis