Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Card14em9Lutzy mutation
(1 available);
any
Card14 mutation
(38 available)
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mortality/aging
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• surviving neonates die after a few days
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growth/size/body
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• surviving neonates are runted
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integument
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• mice exhibit dry flaky skin
• however, mice do not have an epidermal barrier defect
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Card14em9Lutzy mutation
(1 available);
any
Card14 mutation
(38 available)
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integument
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• hyperproliferation of keratinocytes in the basal layer
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• psoriatic skin contains an infiltrate of CD45+ leukocytes composed of increased numbers of neutrophils, myeloid antigen-presenting cells and gamma-delta and alpha-beta T cells
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• epidermis shows presence of microabscesses made up of neutrophils
• however, mice do not have an epidermal barrier defect
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• ears show areas of hyperkeratosis, including parakeratosis and orthokeratosis and keratotic follicular plugging
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• ear tissues show acanthosis due to keratinocyte hyperproliferation and immune cell infiltration of the skin
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• tail skin shows increased thickening of the epidermis
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• mice develop dry flaky skin patches on the back at 5 days of age which begin to disappear at 7 days
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• mice develop dry flaky skin patches on the back at 5 days of age which begin to disappear at 7 days
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• tail skin shows marked hyperplasia with increased thickening of the epidermis and immune cell infiltration
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• mice develop thickened squamous skin on the tail between 2-3 weeks of age and the ears at 4-5 weeks of age, similar to human psoriasis skin lesions
• 100% of adult mice exhibit a chronic psoriatic phenotype with thickened squamous skin of the ears and tail and dry skin around the eyes and whiskers
• tail skin shows marked hyperplasia with increased thickening of the epidermis and immune cell infiltration
• psoriatic skin contains an infiltrate of CD45+ leukocytes composed of increased numbers of neutrophils, myeloid antigen-presenting cells and gamma-delta and alpha-beta T cells
• mice treated with a neutralizing antibody specific for IL-23p19 subunit show a decreased psoriatic phenotype on the ears and tail after 2 weeks of treatment
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immune system
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• psoriatic skin contains an infiltrate of CD45+ leukocytes composed of increased numbers of neutrophils, myeloid antigen-presenting cells and gamma-delta and alpha-beta T cells
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cellular
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• hyperproliferation of keratinocytes in the basal layer
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cardiovascular system
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• increase in the number of enlarged CD31+ blood vessels is seen in the dermis, indicating an increase in dermal vasculature in psoriatic areas
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