All Phenotypes Gt(ROSA)26Sor<em1(ptxA)Btar> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^{em1(ptxA)Btar}/? Tg(Atoh1-cre)1Bfri/?	B6.Cg-Gt(ROSA)26Sor^{em1(ptxA)Btar} Tg(Atoh1-cre)1Bfri/Btar	MGI:6163704
cn2	Foxg1^tm1(cre)Skm/? Gt(ROSA)26Sor^{em1(ptxA)Btar}/?	involves: 129P2/OlaHsd * C57BL/6J	MGI:6163707

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hearing/vestibular/ear

abnormal cochlear hair cell stereociliary bundle morphology ( J:236519 )

• similar to Gpsm2 null homozygotes, the inner hair cells show supernumerary rows of nearly identical stereocilia with a much shortened first row and lacking the normal staircase pattern of heights

abnormal inner hair cell stereociliary bundle morphology ( J:236519 )

short inner hair cell stereocilia ( J:236519 )

abnormal vestibular hair cell stereociliary bundle morphology ( J:236519 )

• in the utricle the vestibular hair cells also have stereocilia that are shortened and have a shallower staircase pattern

increased or absent threshold for auditory brainstem response ( J:236519 )

• almost completely deaf

deafness ( J:236519 )

nervous system

abnormal cochlear hair cell stereociliary bundle morphology ( J:236519 )

• similar to Gpsm2 null homozygotes, the inner hair cells show supernumerary rows of nearly identical stereocilia with a much shortened first row and lacking the normal staircase pattern of heights

abnormal inner hair cell stereociliary bundle morphology ( J:236519 )

short inner hair cell stereocilia ( J:236519 )

abnormal vestibular hair cell stereociliary bundle morphology ( J:236519 )

• in the utricle the vestibular hair cells also have stereocilia that are shortened and have a shallower staircase pattern

Allelic Composition	Foxg1^tm1(cre)Skm/? Gt(ROSA)26Sor^{em1(ptxA)Btar}/?
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxg1^tm1(cre)Skm mutation (2 available); any Foxg1 mutation (28 available)
Gt(ROSA)26Sor^{em1(ptxA)Btar} mutation (0 available); any Gt(ROSA)26Sor mutation (942 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hearing/vestibular/ear

abnormal cochlear hair cell stereociliary bundle morphology ( J:236519 )

• at birth the apical hair cells show severe bundle misorientation

mortality/aging

neonatal lethality, complete penetrance ( J:236519 )

nervous system

abnormal cochlear hair cell stereociliary bundle morphology ( J:236519 )

• at birth the apical hair cells show severe bundle misorientation

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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