Phenotypes associated with this allele

• Allele Symbol: E2f3^{tm1b(KOMP)Wtsi}
• Allele Name: targeted mutation 1b, Wellcome Trust Sanger Institute
• Allele ID: MGI:6160166
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	E2f3^tm1b(KOMP)Wtsi/E2f3^tm1b(KOMP)Wtsi	C57BL/6N-E2f3^tm1b(KOMP)Wtsi/Kmpc	MGI:6394282
ht2	E2f3^tm1b(KOMP)Wtsi/E2f3^+	C57BL/6N-E2f3^tm1b(KOMP)Wtsi/Kmpc	MGI:6370399

Genotype
MGI:6394282

hm1

• Allelic Composition: E2f3^{tm1b(KOMP)Wtsi}/E2f3^{tm1b(KOMP)Wtsi}
• Genetic Background: C57BL/6N-E2f3^{tm1b(KOMP)Wtsi}/Kmpc
• Cell Lines: EPD0034_2_C11

Data Sources

IMPC Data for E2f3

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

no spontaneous movement ( J:211773 )

♀

IMPC - KMPC

embryo

abnormal embryo size ( J:211773 )

♀

IMPC - KMPC

growth/size/body

abnormal embryo size ( J:211773 )

♀

IMPC - KMPC

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - KMPC

Genotype
MGI:6370399

ht2

• Allelic Composition: E2f3^{tm1b(KOMP)Wtsi}/E2f3⁺
• Genetic Background: C57BL/6N-E2f3^{tm1b(KOMP)Wtsi}/Kmpc
• Cell Lines: EPD0034_2_C11

Data Sources

IMPC Data for E2f3

adipose tissue

increased total body fat amount ( J:211773 )

IMPC - KMPC

behavior/neurological

increased startle reflex ( J:211773 )

IMPC - KMPC

no spontaneous movement ( J:211773 )

IMPC - KMPC

cardiovascular system

cornea vascularization ( J:211773 )

IMPC - KMPC

craniofacial

abnormal snout morphology ( J:211773 )

IMPC - KMPC

digestive/alimentary system

abnormal jejunum morphology ( J:211773 )

♂

IMPC - KMPC

growth/size/body

abnormal snout morphology ( J:211773 )

IMPC - KMPC

increased lean body mass ( J:211773 )

IMPC - KMPC

homeostasis/metabolism

impaired glucose tolerance ( J:211773 )

♂

IMPC - KMPC

vision/eye

abnormal cornea morphology ( J:211773 )

IMPC - KMPC

cornea vascularization ( J:211773 )

IMPC - KMPC

cornea opacity ( J:211773 )

IMPC - KMPC