All Phenotypes Slurp2<tm1.1Sgy> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Slurp2^tm1.1Sgy
targeted mutation 1.1, Stephen G Young
MGI:6159751

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slurp2^tm1.1Sgy/Slurp2^tm1.1Sgy	involves: 129P2/OlaHsd * C57BL/6	MGI:6159891
cx2	Slurp1^tm1.1Sgy/Slurp1⁺ Slurp2^tm1.1Sgy/Slurp2⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:6159892

Allelic Composition	Slurp2^tm1.1Sgy/Slurp2^tm1.1Sgy
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slurp2^tm1.1Sgy mutation (0 available); any Slurp2 mutation (13 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

impaired skin barrier function ( J:231067 )

• increased trans-epidermal water loss from paw skin

• trans-epidermal water loss from ear or back skin

abnormal epidermis stratum corneum morphology ( J:231067 )

• contains many tiny lipid droplets in volar surface of paws

hyperkeratosis ( J:231067 )

• on volar surface of paws

homeostasis/metabolism

impaired skin barrier function ( J:231067 )

• increased trans-epidermal water loss from paw skin

• trans-epidermal water loss from ear or back skin

adipose tissue

decreased total fat pad weight ( J:231067 )

decreased percent body fat/body weight ( J:231067 )

growth/size/body

slow postnatal weight gain ( J:231067 )

behavior/neurological

limb grasping ( J:231067 )

• clasping of hindlimbs in tail suspension test

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
palmoplantar keratosis		DOID:3390		J:231067

Allelic Composition	Slurp1^tm1.1Sgy/Slurp1⁺ Slurp2^tm1.1Sgy/Slurp2⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slurp1^tm1.1Sgy mutation (0 available); any Slurp1 mutation (15 available)
Slurp2^tm1.1Sgy mutation (0 available); any Slurp2 mutation (13 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

integument phenotype ( J:231067 )

N	• no hyperkeratosis of paw skin

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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