Analysis Tools
immune system
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• serum titers of OVA-specific IgG antibodies induced by immunization under Th1 and Th2 conditions are moderately elevated
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• serum titers of OVA-specific IgG1 antibodies induced by immunization under Th1 and Th2 conditions are moderately elevated
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• serum titers of OVA-specific IgG2c antibodies induced by immunization under Th1 and Th2 conditions are moderately elevated
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• mice immunized with OVA using adjuvants that favor Th1 responses develop increased numbers of OVA-specific IFN-gamma+ T cells and cells produce more IFN-gamma after in vitro restimulation, indicating enhanced T cell responses
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• mice immunized with OVA using adjuvants that favor Th2 responses develop increased numbers of OVA-specific IL-5+ T cells and cells produce more IL-5 after in vitro restimulation , indicating enhanced T cell responses
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• mice exhibit exacerbated MOG-induced experimental autoimmune encephalopathy (EAE) than wild-type mice, with increased incidence during disease onset and peak disease
• mice with induced EAE show increased spinal cord infiltration by total CD4+ T cells and MOG-specific IFN-gamma+ and IL-17+CD4+ cells, and increased numbers of infiltrating Foxp3+ Treg cells
• ratios between infiltrating Th and Treg are skewed in favor of pathogenic Th1 and Th17 cells
• mice with induced EAE show altered CD4+ T cell responses in draining lymph nodes, with increased frequencies of MOG-specific IFN-gamma+ and IL17+CD4+ T cells at disease onset and peak disease
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• 1 year old mice show increased titers of anti-DNA antibodies
• however, young mice do not exhibit overt signs of spontaneous autoimmunity
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• mice exhibit enhanced effector CD4+ and CD8+ T cell responses to OVA immunization
• however, no alterations in steady-state populations of CD19+ B cells, CD3+ T cells, CD4+ and CD8+ T cells, gamma-delta T cells, NK and NKT cells, plasmacytoid and conventional DCs, LN-resident CD8- and CD8+ DCs, migratory DCs, or double-negative, double-positive, and single-positive thymocytes are seen
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hematopoietic system
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• serum titers of OVA-specific IgG antibodies induced by immunization under Th1 and Th2 conditions are moderately elevated
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• serum titers of OVA-specific IgG1 antibodies induced by immunization under Th1 and Th2 conditions are moderately elevated
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• serum titers of OVA-specific IgG2c antibodies induced by immunization under Th1 and Th2 conditions are moderately elevated
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• mice immunized with OVA using adjuvants that favor Th1 responses develop increased numbers of OVA-specific IFN-gamma+ T cells and cells produce more IFN-gamma after in vitro restimulation, indicating enhanced T cell responses
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• mice immunized with OVA using adjuvants that favor Th2 responses develop increased numbers of OVA-specific IL-5+ T cells and cells produce more IL-5 after in vitro restimulation , indicating enhanced T cell responses
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neoplasm
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• growth of B16-OVA tumors is impaired in OVA-immunized mice and tumors show increased infiltration by conventional DCs, CD4+IFN-gamma+ T cells, CD4+IFN-gamma+IL-17+ T cells and CD8+IFN-gamma+ T cells
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