Phenotypes associated with this allele

• Allele Symbol: Plin3^tm1.1Jbki
• Allele Name: targeted mutation 1.1, Jae Bum Kim
• Allele ID: MGI:6158435
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Plin3^tm1.1Jbki/Plin3^tm1.1Jbki	B6J.129S(Cg)-Plin3^tm1.1Jbki	MGI:6158437

Genotype
MGI:6158437

hm1

• Allelic Composition: Plin3^tm1.1Jbki/Plin3^tm1.1Jbki
• Genetic Background: B6J.129S(Cg)-Plin3^tm1.1Jbki

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

growth/size/body region phenotype ( J:261132 )

N • body weights are similar to controls

adipose tissue

abnormal brown fat cell morphology ( J:261132 )

• multilocular lipid droplets

decreased brown fat cell lipid droplet size ( J:261132 )

• at thermoneutral temperatures but not following cold stimulation

abnormal white fat cell morphology ( J:261132 )

• multilocular lipid droplets in epididymal and inguinal WAT

abnormal inguinal fat pad morphology ( J:261132 )

• at thermoneutral temperatures adipocytes are smaller with multilocular lipid droplets

• at cold temperatures the number of small and multilocular lipid droplets is greatly increased

abnormal beige fat cell physiology ( J:261132 )

• enhanced induction of beige adipocytes with increased lipolytic activities in cold-exposed mice

abnormal white adipose tissue physiology ( J:261132 )

• enhanced expression of thermogenic markers in inguinal WAT from cold exposed mice compared to similarly treated controls

cellular

abnormal mitochondrial physiology ( J:261132 )

• elevated mitochondrial oxygen consumption rates in mitochondria from inguinal WAT

increased fatty acid oxidation ( J:261132 )

• in inguinal WAT from cold-exposed mice

homeostasis/metabolism

decreased susceptibility to induced hypothermia ( J:261132 )

• cold-exposed mice maintain higher body temperatures

• enhanced expression of thermogenic markers in inguinal WAT from cold exposed mice compared to similarly treated controls

increased body temperature ( J:261132 )

• in the presence of the of CL-316,243, a beta3-adrenergic receptor agonist

increased energy expenditure ( J:261132 )

• in the presence of the of CL-316,243, a beta3-adrenergic receptor agonist

increased oxygen consumption ( J:261132 )

• slightly but significantly higher mitochondrial oxygen consumption rates in adipocytes in the basal state and after isoproterenol stimulation

abnormal lipid homeostasis ( J:261132 )

increased fatty acid oxidation ( J:261132 )

• in inguinal WAT from cold-exposed mice

enhanced lipolysis ( J:261132 )

• in both thermoneutral and cold-exposed conditions

abnormal metabolism ( J:261132 )

• appear to exhibit elevated whole-body enery expenditure metabolism parameters at room temperature