Phenotypes associated with this allele

• Allele Symbol: Dpp9^tm1.1Npa
• Allele Name: targeted mutation 1.1, Novartis Pharma AG
• Allele ID: MGI:6157525
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dpp9^tm1.1Npa/Dpp9^tm1.1Npa	involves: C57BL/6	MGI:6157789

Genotype
MGI:6157789

hm1

• Allelic Composition: Dpp9^tm1.1Npa/Dpp9^tm1.1Npa
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:251322 )

• mice die by P1 due to suckling defect

• however, mice bottle fed formula survive the experimental period

digestive/alimentary system

abnormal tongue muscle morphology ( J:251322 )

• failure of longitudinal muscle fibers in intrinsic muscles at the distal part to fully develop

• reduced number and impaired survival of migratory tongue muscle progenitors

• however, mice exhibit normal development of muscles in the proximal part of the tongue and migratory hypaxial muscle progenitors

decreased tongue size ( J:251322 )

• with failure of longitudinal muscle fibers in intrinsic muscles at the distal part to fully develop

growth/size/body

abnormal tongue muscle morphology ( J:251322 )

• failure of longitudinal muscle fibers in intrinsic muscles at the distal part to fully develop

• reduced number and impaired survival of migratory tongue muscle progenitors

• however, mice exhibit normal development of muscles in the proximal part of the tongue and migratory hypaxial muscle progenitors

decreased tongue size ( J:251322 )

• with failure of longitudinal muscle fibers in intrinsic muscles at the distal part to fully develop

decreased body weight ( J:251322 )

• 12 hr after birth

behavior/neurological

absent gastric milk in neonates ( J:251322 )

• however, maternal nursing behavior is normal

abnormal suckling behavior ( J:251322 )

• mice exhibit defective nipple attachment and did not stretch the nipple when they pulled away from the mother

• however, mice are able to locate the nipple and rhythmic jaw motion

craniofacial

craniofacial phenotype ( J:251322 )

N • mice exhibit normal fusion of palatal shelves

abnormal tongue muscle morphology ( J:251322 )

• failure of longitudinal muscle fibers in intrinsic muscles at the distal part to fully develop

• reduced number and impaired survival of migratory tongue muscle progenitors

• however, mice exhibit normal development of muscles in the proximal part of the tongue and migratory hypaxial muscle progenitors

decreased tongue size ( J:251322 )

• with failure of longitudinal muscle fibers in intrinsic muscles at the distal part to fully develop

muscle

abnormal tongue muscle morphology ( J:251322 )

• failure of longitudinal muscle fibers in intrinsic muscles at the distal part to fully develop

• reduced number and impaired survival of migratory tongue muscle progenitors

• however, mice exhibit normal development of muscles in the proximal part of the tongue and migratory hypaxial muscle progenitors